Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 3786164..3786422 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag N4502_RS18270 Protein ID WP_000809168.1
Coordinates 3786164..3786316 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 3786365..3786422 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS18250 3781406..3782119 - 714 WP_001102367.1 acidic protein MsyB -
N4502_RS18255 3782145..3782549 - 405 WP_000843584.1 DUF2541 family protein -
N4502_RS18260 3782925..3784841 + 1917 WP_000516135.1 molecular chaperone DnaK -
N4502_RS18265 3784930..3786060 + 1131 WP_001118454.1 molecular chaperone DnaJ -
N4502_RS18270 3786164..3786316 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 3786365..3786422 + 58 - - Antitoxin
N4502_RS18275 3786902..3788068 + 1167 WP_000681360.1 Na+/H+ antiporter NhaA -
N4502_RS18280 3788134..3789033 + 900 WP_001300855.1 transcriptional activator NhaR -
N4502_RS18285 3789071..3790030 - 960 WP_260837266.1 fimbrial family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T257811 WP_000809168.1 NZ_CP104371:c3786316-3786164 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT257811 NZ_CP104371:3786365-3786422 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References