Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 636674..637236 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name higB Uniprot ID L4J948
Locus tag N4502_RS03160 Protein ID WP_000605676.1
Coordinates 636674..636952 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag N4502_RS03165 Protein ID WP_000781370.1
Coordinates 636952..637236 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS03135 (632260) 632260..632691 - 432 WP_000152305.1 peroxiredoxin OsmC -
N4502_RS03140 (633036) 633036..633251 + 216 WP_000495766.1 biofilm-dependent modulation protein -
N4502_RS03145 (633353) 633353..633490 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
N4502_RS03150 (633647) 633647..635344 + 1698 WP_000433462.1 malate dehydrogenase -
N4502_RS03155 (635478) 635478..636488 + 1011 WP_000642407.1 alcohol dehydrogenase AdhP -
N4502_RS03160 (636674) 636674..636952 + 279 WP_000605676.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4502_RS03165 (636952) 636952..637236 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
N4502_RS03170 (637464) 637464..638117 - 654 WP_000045646.1 formate dehydrogenase-N subunit gamma -
N4502_RS03175 (638110) 638110..638994 - 885 WP_001240582.1 formate dehydrogenase N subunit beta -
N4502_RS03180 (639007) 639007..642054 - 3048 WP_077786070.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10521.10 Da        Isoelectric Point: 7.3562

>T257799 WP_000605676.1 NZ_CP104371:636674-636952 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAASCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT257799 WP_000781370.1 NZ_CP104371:636952-637236 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829G6T1

Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References