Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 104498..105000 Replicon chromosome
Accession NZ_CP104371
Organism Escherichia coli strain 2021CK-01784

Toxin (Protein)


Gene name yoeB Uniprot ID D3GZ85
Locus tag N4502_RS00500 Protein ID WP_000767820.1
Coordinates 104746..105000 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N4502_RS00495 Protein ID WP_001259255.1
Coordinates 104498..104749 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4502_RS00470 (99675) 99675..100742 - 1068 WP_000080071.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N4502_RS00475 (100742) 100742..101812 - 1071 WP_000108970.1 histidinol-phosphate transaminase -
N4502_RS00480 (101809) 101809..103113 - 1305 WP_001306412.1 histidinol dehydrogenase -
N4502_RS00485 (103119) 103119..104018 - 900 WP_000131789.1 ATP phosphoribosyltransferase -
N4502_RS00490 (104164) 104164..104214 - 51 WP_001364200.1 his operon leader peptide -
N4502_RS00495 (104498) 104498..104749 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N4502_RS00500 (104746) 104746..105000 + 255 WP_000767820.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N4502_RS00505 (105083) 105083..105907 + 825 WP_000754757.1 SDR family oxidoreductase -
N4502_RS00510 (105953) 105953..106882 + 930 WP_000803372.1 LysR substrate-binding domain-containing protein -
N4502_RS00515 (107097) 107097..107159 + 63 WP_010723108.1 membrane protein YoeI -
N4502_RS00520 (107149) 107149..108507 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10182.64 Da        Isoelectric Point: 8.0353

>T257794 WP_000767820.1 NZ_CP104371:104746-105000 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257794 WP_001259255.1 NZ_CP104371:104498-104749 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D3GZ85

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References