Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4666600..4667202 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag N4533_RS22700 Protein ID WP_001159630.1
Coordinates 4666891..4667202 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4533_RS22695 Protein ID WP_000362050.1
Coordinates 4666600..4666890 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS22680 (4664093) 4664093..4664995 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
N4533_RS22685 (4664992) 4664992..4665627 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
N4533_RS22690 (4665624) 4665624..4666553 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
N4533_RS22695 (4666600) 4666600..4666890 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
N4533_RS22700 (4666891) 4666891..4667202 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
N4533_RS22705 (4667420) 4667420..4668349 + 930 WP_001127703.1 alpha/beta hydrolase -
N4533_RS22710 (4668435) 4668435..4668746 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
N4533_RS22715 (4668743) 4668743..4669189 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
N4533_RS22720 (4669204) 4669204..4670145 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
N4533_RS22725 (4670190) 4670190..4670627 - 438 WP_000560974.1 D-aminoacyl-tRNA deacylase -
N4533_RS22730 (4670624) 4670624..4671496 - 873 WP_000921427.1 virulence factor BrkB family protein -
N4533_RS22735 (4671490) 4671490..4672089 - 600 WP_000965695.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T257791 WP_001159630.1 NZ_CP104366:c4667202-4666891 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT257791 WP_000362050.1 NZ_CP104366:c4666890-4666600 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References