Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2427079..2427601 Replicon chromosome
Accession NZ_CP104366
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain PNUSAS028809

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag N4533_RS11830 Protein ID WP_000221343.1
Coordinates 2427317..2427601 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag N4533_RS11825 Protein ID WP_000885424.1
Coordinates 2427079..2427327 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4533_RS11800 (2422295) 2422295..2423761 + 1467 WP_000987828.1 hypothetical protein -
N4533_RS11805 (2424569) 2424569..2425283 + 715 Protein_2308 helix-turn-helix domain-containing protein -
N4533_RS11810 (2425339) 2425339..2426247 - 909 WP_010989018.1 hypothetical protein -
N4533_RS11815 (2426390) 2426390..2426722 - 333 WP_000253154.1 DUF1493 family protein -
N4533_RS11820 (2426712) 2426712..2426927 - 216 WP_000206207.1 hypothetical protein -
N4533_RS11825 (2427079) 2427079..2427327 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4533_RS11830 (2427317) 2427317..2427601 + 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4533_RS11835 (2427772) 2427772..2428161 + 390 WP_000194089.1 RidA family protein -
N4533_RS11840 (2428213) 2428213..2429292 - 1080 WP_000954688.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
N4533_RS11845 (2429485) 2429485..2429973 - 489 WP_001293638.1 MarR family winged helix-turn-helix transcriptional regulator -
N4533_RS11850 (2430018) 2430018..2431526 + 1509 WP_000199411.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 2422298..2434383 12085


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T257784 WP_000221343.1 NZ_CP104366:2427317-2427601 [Salmonella enterica subsp. enterica serovar Typhimurium]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT257784 WP_000885424.1 NZ_CP104366:2427079-2427327 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References