Detailed information of TA system TA257760

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2443964..2444189
• Replicon: chromosome
• Accession: NZ_CP104362
• Organism: Salmonella enterica strain PNUSAS118606

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: N4276_RS11890
• Protein ID: WP_000813254.1
• Coordinates: 2443964..2444119 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2444131..2444189 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
N4276_RS11855	2439071..2439352	-	282	WP_000445513.1	phage holin family protein	-
N4276_RS11860	2439342..2439530	-	189	WP_001688615.1	putative holin	-
N4276_RS11865	2439524..2439847	-	324	Protein_2323	tellurite/colicin resistance protein	-
N4276_RS11870	2442018..2442554	-	537	WP_000640113.1	DUF1133 family protein	-
N4276_RS11875	2442551..2442841	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
N4276_RS11880	2442841..2443440	-	600	WP_000940751.1	DUF1367 family protein	-
N4276_RS11885	2443503..2443673	-	171	WP_000734094.1	hypothetical protein	-
N4276_RS11890	2443964..2444119	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	2444131..2444189	+	59	-	-	Antitoxin
N4276_RS11895	2444546..2445478	+	933	WP_000556390.1	hypothetical protein	-
N4276_RS11900	2445475..2446029	+	555	WP_001033796.1	hypothetical protein	-
N4276_RS11905	2446191..2446520	-	330	WP_001676916.1	DUF977 family protein	-
N4276_RS11910	2446564..2446611	-	48	Protein_2332	hypothetical protein	-
N4276_RS11915	2446793..2447260	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
N4276_RS11920	2447645..2447800	+	156	WP_085981757.1	DUF1391 family protein	-
N4276_RS11925	2447908..2448429	-	522	WP_000004762.1	super-infection exclusion protein B	-
N4276_RS11930	2448867..2449088	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2438529..2450400	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T257760 WP_000813254.1 NZ_CP104362:c2444119-2443964 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

Antitoxin

Nucleotide

• Length: 59 bp

>AT257760 NZ_CP104362:2444131-2444189 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin