257712

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1139486..1140084 Replicon chromosome
Accession NZ_CP104354
Organism Vibrio cholerae strain PNUSAV001140

Toxin (Protein)


Gene name higB Uniprot ID I1YFL9
Locus tag N4267_RS05350 Protein ID WP_001896384.1
Coordinates 1139761..1140084 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4267_RS05345 Protein ID WP_000058216.1
Coordinates 1139486..1139764 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4267_RS05330 (N4267_05330) 1136448..1138268 + 1821 WP_032468029.1 conjugative transfer system coupling protein TraD -
N4267_RS05335 (N4267_05335) 1138278..1138838 + 561 WP_001896321.1 hypothetical protein -
N4267_RS05340 (N4267_05340) 1138825..1139460 + 636 WP_001896322.1 DUF4400 domain-containing protein -
N4267_RS05345 (N4267_05345) 1139486..1139764 - 279 WP_000058216.1 helix-turn-helix transcriptional regulator Antitoxin
N4267_RS05350 (N4267_05350) 1139761..1140084 - 324 WP_001896384.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4267_RS05355 (N4267_05355) 1140265..1140546 + 282 WP_000433891.1 type IV conjugative transfer system protein TraL -
N4267_RS05360 (N4267_05360) 1140543..1141169 + 627 WP_001896361.1 TraE/TraK family type IV conjugative transfer system protein -
N4267_RS05365 (N4267_05365) 1141153..1142049 + 897 WP_001896336.1 type-F conjugative transfer system secretin TraK -
N4267_RS05370 (N4267_05370) 1142052..1143341 + 1290 WP_134987188.1 TraB/VirB10 family protein -
N4267_RS05375 (N4267_05375) 1143416..1143988 + 573 WP_147422779.1 type IV conjugative transfer system lipoprotein TraV -
N4267_RS05380 (N4267_05380) 1143985..1144371 + 387 WP_001896311.1 TraA family conjugative transfer protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1124504..1229432 104928


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12281.33 Da        Isoelectric Point: 9.7658

>T257712 WP_001896384.1 NZ_CP104354:c1140084-1139761 [Vibrio cholerae]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGKHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10517.07 Da        Isoelectric Point: 9.9393

>AT257712 WP_000058216.1 NZ_CP104354:c1139764-1139486 [Vibrio cholerae]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A244CN87

Antitoxin

Source ID Structure

References