Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-RelB |
Location | 156964..157477 | Replicon | plasmid AZO_p3 |
Accession | NC_016623 | ||
Organism | Azospirillum lipoferum 4B |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | G7ZF26 |
Locus tag | AZOLI_RS22305 | Protein ID | WP_014249446.1 |
Coordinates | 156964..157230 (-) | Length | 89 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | A0A6N1ADX4 |
Locus tag | AZOLI_RS22310 | Protein ID | WP_044552781.1 |
Coordinates | 157211..157477 (-) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
AZOLI_RS22280 | 152921..153763 | + | 843 | WP_162488376.1 | GntR family transcriptional regulator | - |
AZOLI_RS22285 | 153842..154660 | + | 819 | WP_014249442.1 | transporter substrate-binding domain-containing protein | - |
AZOLI_RS22290 | 154726..155373 | + | 648 | WP_014249443.1 | amino acid ABC transporter permease | - |
AZOLI_RS22295 | 155378..156082 | + | 705 | WP_014249444.1 | amino acid ABC transporter permease | - |
AZOLI_RS22300 | 156145..156909 | + | 765 | WP_162488402.1 | amino acid ABC transporter ATP-binding protein | - |
AZOLI_RS22305 | 156964..157230 | - | 267 | WP_014249446.1 | Txe/YoeB family addiction module toxin | Toxin |
AZOLI_RS22310 | 157211..157477 | - | 267 | WP_044552781.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
AZOLI_RS22315 | 157651..158325 | + | 675 | WP_014249448.1 | ATP-binding cassette domain-containing protein | - |
AZOLI_RS22320 | 158325..158972 | + | 648 | WP_014249449.1 | energy-coupling factor transporter transmembrane protein EcfT | - |
AZOLI_RS22325 | 159003..159548 | + | 546 | WP_044553011.1 | biotin transporter BioY | - |
AZOLI_RS22330 | 159553..161040 | + | 1488 | WP_044552784.1 | AMP-binding protein | - |
AZOLI_RS22335 | 161037..162206 | + | 1170 | WP_014249452.1 | thiolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | adeG | 1..648491 | 648491 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10252.67 Da Isoelectric Point: 9.4087
>T25770 WP_014249446.1 NC_016623:c157230-156964 [Azospirillum lipoferum 4B]
MKKVWTDGAWEDYLYWQKNDQAVLKKVNDLIRDTERNPFSGLGKPEPLKEGLAGWWSRRITGEHRLVYRVTGSGAAQALE
ILACRYHY
MKKVWTDGAWEDYLYWQKNDQAVLKKVNDLIRDTERNPFSGLGKPEPLKEGLAGWWSRRITGEHRLVYRVTGSGAAQALE
ILACRYHY
Download Length: 267 bp
>T25770 NC_016623:c157230-156964 [Azospirillum lipoferum 4B]
ATGAAGAAGGTTTGGACTGACGGCGCTTGGGAGGATTACTTATACTGGCAGAAGAACGACCAGGCCGTGTTGAAGAAGGT
CAACGATCTGATCCGCGACACTGAAAGGAACCCGTTCTCAGGACTGGGCAAGCCTGAACCCCTGAAGGAAGGGCTTGCCG
GCTGGTGGTCGCGCCGCATCACGGGCGAACATCGGCTGGTCTATCGGGTGACCGGGAGCGGTGCCGCCCAAGCACTCGAA
ATACTGGCCTGCCGGTATCACTACTGA
ATGAAGAAGGTTTGGACTGACGGCGCTTGGGAGGATTACTTATACTGGCAGAAGAACGACCAGGCCGTGTTGAAGAAGGT
CAACGATCTGATCCGCGACACTGAAAGGAACCCGTTCTCAGGACTGGGCAAGCCTGAACCCCTGAAGGAAGGGCTTGCCG
GCTGGTGGTCGCGCCGCATCACGGGCGAACATCGGCTGGTCTATCGGGTGACCGGGAGCGGTGCCGCCCAAGCACTCGAA
ATACTGGCCTGCCGGTATCACTACTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 9798.17 Da Isoelectric Point: 4.6768
>AT25770 WP_044552781.1 NC_016623:c157477-157211 [Azospirillum lipoferum 4B]
MGHISYTDLRNNLASVMDEVCDSRAPLTVTRQKGRSVVMISEEEFEGLMETLHLLKSPKNAERLLKGIAQLDAGKGIERD
ILNEEGLD
MGHISYTDLRNNLASVMDEVCDSRAPLTVTRQKGRSVVMISEEEFEGLMETLHLLKSPKNAERLLKGIAQLDAGKGIERD
ILNEEGLD
Download Length: 267 bp
>AT25770 NC_016623:c157477-157211 [Azospirillum lipoferum 4B]
ATGGGTCACATCAGCTACACCGATCTTAGAAACAACCTTGCCAGCGTGATGGACGAGGTCTGTGACAGCCGCGCGCCGCT
GACCGTCACCCGTCAGAAGGGACGGTCGGTGGTGATGATTTCCGAGGAAGAATTCGAAGGGCTGATGGAGACGCTTCATC
TCCTGAAAAGCCCCAAAAACGCGGAACGGCTGCTCAAGGGCATCGCCCAACTTGATGCGGGCAAAGGCATCGAGCGGGAC
ATTCTGAATGAAGAAGGTTTGGACTGA
ATGGGTCACATCAGCTACACCGATCTTAGAAACAACCTTGCCAGCGTGATGGACGAGGTCTGTGACAGCCGCGCGCCGCT
GACCGTCACCCGTCAGAAGGGACGGTCGGTGGTGATGATTTCCGAGGAAGAATTCGAAGGGCTGATGGAGACGCTTCATC
TCCTGAAAAGCCCCAAAAACGCGGAACGGCTGCTCAAGGGCATCGCCCAACTTGATGCGGGCAAAGGCATCGAGCGGGAC
ATTCTGAATGAAGAAGGTTTGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | G7ZF26 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6N1ADX4 |