Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 149650..150235 Replicon plasmid unnamed2
Accession NZ_CP104345
Organism Acinetobacter baumannii strain 2021CK-01332

Toxin (Protein)


Gene name higB Uniprot ID N9CJF7
Locus tag N4T36_RS00620 Protein ID WP_000897307.1
Coordinates 149650..149970 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4T36_RS00625 Protein ID WP_000369781.1
Coordinates 149963..150235 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T36_RS00580 (N4T36_00580) 144955..145791 + 837 WP_040110386.1 APH(6)-I family aminoglycoside O-phosphotransferase -
N4T36_RS00585 (N4T36_00585) 145981..146268 + 288 WP_000438825.1 BrnT family toxin -
N4T36_RS00590 (N4T36_00590) 146255..146569 + 315 WP_004728120.1 BrnA antitoxin family protein -
N4T36_RS00595 (N4T36_00595) 146736..147179 - 444 WP_260744098.1 hypothetical protein -
N4T36_RS00600 (N4T36_00600) 147257..148225 + 969 WP_252513945.1 IS30 family transposase -
N4T36_RS00605 (N4T36_00605) 148427..148729 + 303 WP_000286964.1 type II toxin-antitoxin system RelE/ParE family toxin -
N4T36_RS00610 (N4T36_00610) 148730..149011 + 282 WP_000985609.1 putative addiction module antidote protein -
N4T36_RS00615 (N4T36_00615) 149091..149510 - 420 WP_001180106.1 SMI1/KNR4 family protein -
N4T36_RS00620 (N4T36_00620) 149650..149970 + 321 WP_000897307.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4T36_RS00625 (N4T36_00625) 149963..150235 + 273 WP_000369781.1 NadS family protein Antitoxin
N4T36_RS00630 (N4T36_00630) 150728..152203 + 1476 WP_000052512.1 ABC-F type ribosomal protection protein Msr(E) -
N4T36_RS00635 (N4T36_00635) 152259..153143 + 885 WP_000155092.1 Mph(E) family macrolide 2'-phosphotransferase -
N4T36_RS00640 (N4T36_00640) 153333..153944 - 612 WP_015060246.1 recombinase family protein -
N4T36_RS00645 (N4T36_00645) 154200..154616 + 417 WP_000147519.1 hypothetical protein -
N4T36_RS00650 (N4T36_00650) 154637..154879 + 243 WP_001229660.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(X3) / sul2 / aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) / ARR-3 / qacE / sul1 / blaNDM-1 / aph(3')-VI / blaOXA-58 - 1..338291 338291
- inside IScluster/Tn aph(3'')-Ib / aph(6)-Id / msr(E) / mph(E) - 135314..153143 17829


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(41-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-85)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12187.95 Da        Isoelectric Point: 7.1639

>T257697 WP_000897307.1 NZ_CP104345:149650-149970 [Acinetobacter baumannii]
MLFIETSIFTKQIKDLVSDEEYRQLQQDLLVQPDRGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSVKDNLTDKETAILHQLVKEQFHG

Download         Length: 321 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10149.61 Da        Isoelectric Point: 8.6582

>AT257697 WP_000369781.1 NZ_CP104345:149963-150235 [Acinetobacter baumannii]
MDNNLFDDLVASIKEAGAIKRKEVKASRVTELELPDIKEVREKTGLSQNEFAARLHISPRTLQNWEQGRRYPTGPAATLI
RILDAHPSLI

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8TMZ3

Antitoxin

Source ID Structure

References