257654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1790523..1791025 Replicon chromosome
Accession NZ_CP104330
Organism Escherichia coli strain THB42-F3

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N0544_RS08500 Protein ID WP_000767829.1
Coordinates 1790771..1791025 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N0544_RS08495 Protein ID WP_001259255.1
Coordinates 1790523..1790774 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0544_RS08470 (1785701) 1785701..1786768 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N0544_RS08475 (1786768) 1786768..1787838 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
N0544_RS08480 (1787835) 1787835..1789139 - 1305 WP_000009594.1 histidinol dehydrogenase -
N0544_RS08485 (1789145) 1789145..1790044 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N0544_RS08490 (1790190) 1790190..1790240 - 51 WP_001364200.1 his operon leader peptide -
N0544_RS08495 (1790523) 1790523..1790774 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N0544_RS08500 (1790771) 1790771..1791025 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N0544_RS08505 (1791108) 1791108..1791932 + 825 WP_000754737.1 SDR family oxidoreductase -
N0544_RS08510 (1791978) 1791978..1792907 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N0544_RS08515 (1793122) 1793122..1793184 + 63 WP_010723108.1 membrane protein YoeI -
N0544_RS08520 (1793174) 1793174..1794532 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N0544_RS08525 (1794711) 1794711..1795769 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
N0544_RS08530 (1795783) 1795783..1796010 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257654 WP_000767829.1 NZ_CP104330:1790771-1791025 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257654 WP_001259255.1 NZ_CP104330:1790523-1790774 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References