Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3903279..3903691 Replicon chromosome
Accession NZ_CP104328
Organism Escherichia coli strain THB42-F2

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag N0499_RS19045 Protein ID WP_000132601.1
Coordinates 3903350..3903691 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3903279..3903355 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0499_RS19035 (3900142) 3900142..3901731 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
N0499_RS19040 (3901728) 3901728..3903122 + 1395 WP_072647344.1 type I restriction-modification system specificity subunit -
- (3903279) 3903279..3903355 - 77 NuclAT_14 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_14 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_14 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_14 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_15 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_15 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_15 - Antitoxin
- (3903279) 3903279..3903355 - 77 NuclAT_15 - Antitoxin
N0499_RS19045 (3903350) 3903350..3903691 + 342 WP_000132601.1 endoribonuclease SymE Toxin
N0499_RS19050 (3903853) 3903853..3905232 + 1380 WP_072647343.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
N0499_RS19055 (3905232) 3905232..3906278 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T257637 WP_000132601.1 NZ_CP104328:3903350-3903691 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT257637 NZ_CP104328:c3903355-3903279 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References