257593

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1796634..1797136 Replicon chromosome
Accession NZ_CP104326
Organism Escherichia coli strain THB42-F1

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N0470_RS08545 Protein ID WP_000767829.1
Coordinates 1796882..1797136 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N0470_RS08540 Protein ID WP_001259255.1
Coordinates 1796634..1796885 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0470_RS08515 (1791812) 1791812..1792879 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N0470_RS08520 (1792879) 1792879..1793949 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
N0470_RS08525 (1793946) 1793946..1795250 - 1305 WP_000009594.1 histidinol dehydrogenase -
N0470_RS08530 (1795256) 1795256..1796155 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N0470_RS08535 (1796301) 1796301..1796351 - 51 WP_001364200.1 his operon leader peptide -
N0470_RS08540 (1796634) 1796634..1796885 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N0470_RS08545 (1796882) 1796882..1797136 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N0470_RS08550 (1797219) 1797219..1798043 + 825 WP_000754737.1 SDR family oxidoreductase -
N0470_RS08555 (1798089) 1798089..1799018 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N0470_RS08560 (1799233) 1799233..1799295 + 63 WP_010723108.1 membrane protein YoeI -
N0470_RS08565 (1799285) 1799285..1800643 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N0470_RS08570 (1800822) 1800822..1801880 + 1059 WP_000492339.1 thiosulfate utilization transporter TsuA/YeeE -
N0470_RS08575 (1801894) 1801894..1802121 + 228 WP_000234896.1 sulfurtransferase TusA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257593 WP_000767829.1 NZ_CP104326:1796882-1797136 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257593 WP_001259255.1 NZ_CP104326:1796634-1796885 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References