Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2502..2771 Replicon plasmid pKP81323
Accession NZ_CP104315
Organism Klebsiella pneumoniae strain KP8132

Toxin (Protein)


Gene name hok Uniprot ID G9G195
Locus tag N2X67_RS27160 Protein ID WP_001323520.1
Coordinates 2655..2771 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name sok
Locus tag -
Coordinates 2502..2567 (-)

Genomic Context


N2X67_RS27140N2X67_RS27145N2X67_RS27150----N2X67_RS27155N2X67_RS27160N2X67_RS27170N2X67_RS27175N2X67_RS27185N2X67_RS27190--N2X67_RS27165N2X67_RS27180
Location: 707..1114 (408 bp)
Type: Others
Protein ID: WP_228706454.1
Location: 1183..1617 (435 bp)
Type: Others
Protein ID: WP_000845953.1
Location: 1614..2333 (720 bp)
Type: Others
Protein ID: WP_001276217.1
Location: 2345..2569 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 2345..2569 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 2345..2569 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 2345..2569 (225 bp)
Type: Others
Protein ID: NuclAT_0
Location: 2555..2704 (150 bp)
Type: Others
Protein ID: Protein_4
Location: 2655..2771 (117 bp)
Type: Toxin
Protein ID: WP_001323520.1
Location: 3685..3981 (297 bp)
Type: Others
Protein ID: WP_001272251.1
Location: 4092..4913 (822 bp)
Type: Others
Protein ID: WP_001234445.1
Location: 6134..6517 (384 bp)
Type: Others
Protein ID: WP_000124981.1
Location: 6798..7502 (705 bp)
Type: Others
Protein ID: WP_001067855.1
Location: 2502..2567 (66 bp)
Type: Antitoxin
Protein ID: -
Location: 3090..3386 (297 bp)
Type: Others
Protein ID: Protein_6
Location: 5210..5857 (648 bp)
Type: Others
Protein ID: WP_015059008.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
N2X67_RS27140707..1114+408WP_228706454.1hypothetical protein-
N2X67_RS271451183..1617+435WP_000845953.1conjugation system SOS inhibitor PsiB-
N2X67_RS271501614..2333+720WP_001276217.1plasmid SOS inhibition protein A-
-2345..2569+225NuclAT_0--
-2345..2569+225NuclAT_0--
-2345..2569+225NuclAT_0--
-2345..2569+225NuclAT_0--
-2502..2567-66--Antitoxin
N2X67_RS271552555..2704+150Protein_4plasmid maintenance protein Mok-
N2X67_RS271602655..2771+117WP_001323520.1type I toxin-antitoxin system Hok family toxinToxin
N2X67_RS271653090..3386-297Protein_6hypothetical protein-
N2X67_RS271703685..3981+297WP_001272251.1hypothetical protein-
N2X67_RS271754092..4913+822WP_001234445.1DUF932 domain-containing protein-
N2X67_RS271805210..5857-648WP_015059008.1transglycosylase SLT domain-containing protein-
N2X67_RS271856134..6517+384WP_000124981.1conjugal transfer relaxosome DNA-binding protein TraM-
N2X67_RS271906798..7502+705WP_001067855.1IS6-like element IS26 family transposase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideMobilizable plasmidblaSHV-12 / blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB-1..135468135468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-34)


Sequences


Toxin        


Download         Length: 39 a.a.        Molecular weight: 4455.23 Da        Isoelectric Point: 8.5110

>T257573 WP_001323520.1 NZ_CP104315:2655-2771 [Klebsiella pneumoniae]
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Download         Length: 117 bp


Antitoxin


Download         Length: 66 bp

>AT257573 NZ_CP104315:c2567-2502 [Klebsiella pneumoniae]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBG9G195


Antitoxin

Download structure file

References