Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 2345..2771 | Replicon | plasmid pKP81323 |
| Accession | NZ_CP104315 | ||
| Organism | Klebsiella pneumoniae strain KP8132 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | G9G195 |
| Locus tag | N2X67_RS27160 | Protein ID | WP_001323520.1 |
| Coordinates | 2655..2771 (+) | Length | 39 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 2345..2569 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| N2X67_RS27140 (707) | 707..1114 | + | 408 | WP_228706454.1 | hypothetical protein | - |
| N2X67_RS27145 (1183) | 1183..1617 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| N2X67_RS27150 (1614) | 1614..2333 | + | 720 | WP_001276217.1 | plasmid SOS inhibition protein A | - |
| - (2345) | 2345..2569 | + | 225 | NuclAT_0 | - | Antitoxin |
| - (2345) | 2345..2569 | + | 225 | NuclAT_0 | - | Antitoxin |
| - (2345) | 2345..2569 | + | 225 | NuclAT_0 | - | Antitoxin |
| - (2345) | 2345..2569 | + | 225 | NuclAT_0 | - | Antitoxin |
| N2X67_RS27155 (2555) | 2555..2704 | + | 150 | Protein_4 | plasmid maintenance protein Mok | - |
| N2X67_RS27160 (2655) | 2655..2771 | + | 117 | WP_001323520.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| N2X67_RS27165 (3090) | 3090..3386 | - | 297 | Protein_6 | hypothetical protein | - |
| N2X67_RS27170 (3685) | 3685..3981 | + | 297 | WP_001272251.1 | hypothetical protein | - |
| N2X67_RS27175 (4092) | 4092..4913 | + | 822 | WP_001234445.1 | DUF932 domain-containing protein | - |
| N2X67_RS27180 (5210) | 5210..5857 | - | 648 | WP_015059008.1 | transglycosylase SLT domain-containing protein | - |
| N2X67_RS27185 (6134) | 6134..6517 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| N2X67_RS27190 (6798) | 6798..7502 | + | 705 | WP_001067855.1 | IS6-like element IS26 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | blaSHV-12 / blaKPC-2 / blaCTX-M-65 / blaTEM-1B / rmtB | - | 1..135468 | 135468 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 39 a.a. Molecular weight: 4455.23 Da Isoelectric Point: 8.5110
>T257572 WP_001323520.1 NZ_CP104315:2655-2771 [Klebsiella pneumoniae]
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 117 bp
Antitoxin
Download Length: 225 bp
>AT257572 NZ_CP104315:2345-2569 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
