257550

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4713439..4713851 Replicon chromosome
Accession NZ_CP104309
Organism Escherichia coli O157:H7 strain 380-94

Toxin (Protein)


Gene name symE Uniprot ID Q8FA88
Locus tag NUE46_RS23785 Protein ID WP_000132630.1
Coordinates 4713510..4713851 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4713439..4713515 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NUE46_RS23775 (4710066) 4710066..4711535 + 1470 WP_001302468.1 type I restriction-modification system subunit M -
NUE46_RS23780 (4711535) 4711535..4713289 + 1755 WP_000110082.1 restriction endonuclease subunit S -
- (4713439) 4713439..4713515 - 77 NuclAT_15 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_15 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_15 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_15 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_16 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_16 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_16 - Antitoxin
- (4713439) 4713439..4713515 - 77 NuclAT_16 - Antitoxin
NUE46_RS23785 (4713510) 4713510..4713851 + 342 WP_000132630.1 endoribonuclease SymE Toxin
NUE46_RS23790 (4713898) 4713898..4715061 - 1164 WP_001304006.1 DUF1524 domain-containing protein -
NUE46_RS23795 (4715109) 4715109..4715990 - 882 WP_001304007.1 DUF262 domain-containing protein -
NUE46_RS23800 (4716133) 4716133..4716285 - 153 WP_001418365.1 hypothetical protein -
NUE46_RS23805 (4716428) 4716428..4717840 + 1413 WP_000199295.1 PLP-dependent aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - espX6 4705638..4726871 21233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12294.13 Da        Isoelectric Point: 8.4982

>T257550 WP_000132630.1 NZ_CP104309:4713510-4713851 [Escherichia coli O157:H7]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTVVDVKVMEGCIVLTAQPPAAAESE
LMQSLRQVCKLSARKQRQVQEFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT257550 NZ_CP104309:c4713515-4713439 [Escherichia coli O157:H7]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y5T0

Antitoxin

Download structure file

References