257525

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 1805278..1805842 Replicon chromosome
Accession NZ_CP104303
Organism Lacticaseibacillus paracasei strain VHProbi O44

Toxin (Protein)


Gene name yafQ Uniprot ID A0A510WIJ9
Locus tag N4T21_RS08810 Protein ID WP_016363448.1
Coordinates 1805278..1805580 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID K6SLT0
Locus tag N4T21_RS08815 Protein ID WP_003570051.1
Coordinates 1805573..1805842 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4T21_RS08790 (N4T21_08790) 1800591..1801148 + 558 WP_260642700.1 helix-turn-helix transcriptional regulator -
N4T21_RS08795 (N4T21_08795) 1801573..1803750 - 2178 WP_260642701.1 Tex family protein -
N4T21_RS08800 (N4T21_08800) 1803986..1804678 - 693 WP_003570055.1 hypothetical protein -
N4T21_RS08805 (N4T21_08805) 1804796..1804939 - 144 WP_162259784.1 hypothetical protein -
N4T21_RS08810 (N4T21_08810) 1805278..1805580 - 303 WP_016363448.1 type II toxin-antitoxin system YafQ family toxin Toxin
N4T21_RS08815 (N4T21_08815) 1805573..1805842 - 270 WP_003570051.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N4T21_RS08820 (N4T21_08820) 1806216..1806869 - 654 WP_003570049.1 N-acetyltransferase -
N4T21_RS08825 (N4T21_08825) 1806914..1807543 - 630 WP_003570047.1 DUF2399 domain-containing protein -
N4T21_RS08830 (N4T21_08830) 1807606..1807932 - 327 WP_003584272.1 YrdB family protein -
N4T21_RS08835 (N4T21_08835) 1807925..1808329 - 405 WP_003570045.1 MerR family transcriptional regulator -
N4T21_RS08840 (N4T21_08840) 1808527..1809753 + 1227 WP_003570043.1 hypothetical protein -
N4T21_RS08845 (N4T21_08845) 1809950..1810837 + 888 WP_003570041.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-97)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(10-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11510.33 Da        Isoelectric Point: 9.8881

>T257525 WP_016363448.1 NZ_CP104303:c1805580-1805278 [Lacticaseibacillus paracasei]
MYSLVPTPTFKRDLKRLSKKHWPMDELKTAVNLLAAGTNAELLSKKYADHALSSSSEWKGYRELYVDGPRGDWLLIYKIE
QQDLILTLVRTGSHHNLLVK

Download         Length: 303 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9982.68 Da        Isoelectric Point: 7.2026

>AT257525 WP_003570051.1 NZ_CP104303:c1805842-1805573 [Lacticaseibacillus paracasei]
MAATKKETRLNIRVDPELKSAAQIVANDMGIDLTAAVTMFMTKMVKDHALPFTPTSLPVETLQALKEAKHPELLKKYSTP
DDMWRDLNV

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A510WIJ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E2BRK6

References