257509

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5243092..5243687 Replicon chromosome
Accession NZ_CP104301
Organism Pseudomonas aeruginosa strain PLL01

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag N4Q74_RS24315 Protein ID WP_003113526.1
Coordinates 5243409..5243687 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4Q74_RS24310 Protein ID WP_003113527.1
Coordinates 5243092..5243397 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4Q74_RS24275 5238231..5239079 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
N4Q74_RS24285 5239246..5240187 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
N4Q74_RS24290 5240304..5240918 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
N4Q74_RS24295 5240960..5241544 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
N4Q74_RS24300 5241585..5242685 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
N4Q74_RS24310 5243092..5243397 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
N4Q74_RS24315 5243409..5243687 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4Q74_RS24320 5243740..5243868 - 129 Protein_4803 integrase -
N4Q74_RS24325 5244016..5246244 + 2229 WP_003113525.1 TonB-dependent receptor -
N4Q74_RS24330 5246314..5246961 - 648 WP_003095021.1 carbonate dehydratase -
N4Q74_RS24335 5247023..5248261 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T257509 WP_003113526.1 NZ_CP104301:c5243687-5243409 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT257509 WP_003113527.1 NZ_CP104301:c5243397-5243092 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References