Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 800215..800823 Replicon chromosome
Accession NZ_CP104301
Organism Pseudomonas aeruginosa strain PLL01

Toxin (Protein)


Gene name PfiT Uniprot ID Q9I5J9
Locus tag N4Q74_RS03780 Protein ID WP_003114156.1
Coordinates 800476..800823 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag N4Q74_RS03775 Protein ID WP_003114155.1
Coordinates 800215..800466 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4Q74_RS03755 795862..796218 + 357 WP_003114150.1 DUF2523 family protein -
N4Q74_RS03760 796222..797496 + 1275 WP_010895520.1 zonular occludens toxin family protein -
N4Q74_RS03765 797726..799018 + 1293 WP_003115206.1 hypothetical protein -
N4Q74_RS03770 799018..800001 + 984 WP_003114154.1 tyrosine-type recombinase/integrase -
N4Q74_RS03775 800215..800466 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N4Q74_RS03780 800476..800823 + 348 WP_003114156.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4Q74_RS03790 801150..802052 - 903 WP_003114157.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
N4Q74_RS03795 802504..803241 - 738 WP_003114158.1 murein L,D-transpeptidase catalytic domain family protein -
N4Q74_RS03800 803321..804364 - 1044 WP_003098363.1 L,D-transpeptidase -
N4Q74_RS03805 804500..805192 - 693 WP_003114159.1 16S rRNA pseudouridine(516) synthase -
N4Q74_RS03810 805192..805464 - 273 WP_010895521.1 cysteine-rich CWC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 786234..800823 14589
inside Prophage - - 787977..800823 12846


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12984.78 Da        Isoelectric Point: 4.4212

>T257505 WP_003114156.1 NZ_CP104301:800476-800823 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEVAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT257505 WP_003114155.1 NZ_CP104301:800215-800466 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9I5J9

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References