Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26165..26823 Replicon plasmid pZHOU-2
Accession NZ_CP104299
Organism Acinetobacter baumannii strain ZHOU

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N2K92_RS20080 Protein ID WP_000312250.1
Coordinates 26464..26823 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2K92_RS20075 Protein ID WP_001096429.1
Coordinates 26165..26464 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K92_RS20040 (N2K92_20055) 22223..22480 + 258 WP_071210684.1 hypothetical protein -
N2K92_RS20045 (N2K92_20060) 22485..23057 + 573 WP_071210685.1 hypothetical protein -
N2K92_RS20050 (N2K92_20065) 23033..23212 + 180 WP_002081921.1 hypothetical protein -
N2K92_RS20055 (N2K92_20070) 23229..23858 + 630 WP_071210686.1 hypothetical protein -
N2K92_RS20060 (N2K92_20075) 23898..24407 + 510 WP_001043200.1 hypothetical protein -
N2K92_RS20065 (N2K92_20080) 24488..25042 + 555 WP_071210687.1 hypothetical protein -
N2K92_RS20070 (N2K92_20085) 25092..25628 + 537 WP_000731980.1 hypothetical protein -
N2K92_RS20075 (N2K92_20090) 26165..26464 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
N2K92_RS20080 (N2K92_20095) 26464..26823 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2K92_RS20085 (N2K92_20100) 27024..27590 + 567 WP_000710385.1 hypothetical protein -
N2K92_RS20090 (N2K92_20105) 27639..27821 + 183 WP_000373385.1 hypothetical protein -
N2K92_RS20095 (N2K92_20110) 27888..28586 + 699 WP_000873190.1 hypothetical protein -
N2K92_RS20100 (N2K92_20115) 28725..29108 + 384 WP_071210698.1 hypothetical protein -
N2K92_RS20105 (N2K92_20120) 29169..29927 + 759 WP_071210697.1 hypothetical protein -
N2K92_RS20110 (N2K92_20125) 29978..30313 + 336 WP_071210696.1 hypothetical protein -
N2K92_RS20115 (N2K92_20130) 31180..31494 + 315 WP_071210660.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..72233 72233


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T257503 WP_000312250.1 NZ_CP104299:c26823-26464 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT257503 WP_001096429.1 NZ_CP104299:c26464-26165 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References