Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 26912..27570 Replicon plasmid pDETAB-C9-1
Accession NZ_CP104296
Organism Acinetobacter baumannii strain DETAB-C9

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N4Q44_RS19135 Protein ID WP_000312250.1
Coordinates 27211..27570 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N4Q44_RS19130 Protein ID WP_001096429.1
Coordinates 26912..27211 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N4Q44_RS19100 (N4Q44_19110) 22932..23582 + 651 WP_139845924.1 hypothetical protein -
N4Q44_RS19105 (N4Q44_19115) 23622..24131 + 510 WP_001043199.1 hypothetical protein -
N4Q44_RS19110 (N4Q44_19120) 24212..24766 + 555 WP_038345807.1 hypothetical protein -
N4Q44_RS19115 (N4Q44_19125) 24816..25352 + 537 WP_000731981.1 hypothetical protein -
N4Q44_RS19120 (N4Q44_19130) 25973..26455 + 483 WP_001052677.1 hypothetical protein -
N4Q44_RS19125 (N4Q44_19135) 26548..26811 - 264 WP_000110863.1 hypothetical protein -
N4Q44_RS19130 (N4Q44_19140) 26912..27211 - 300 WP_001096429.1 XRE family transcriptional regulator Antitoxin
N4Q44_RS19135 (N4Q44_19145) 27211..27570 - 360 WP_000312250.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N4Q44_RS19140 (N4Q44_19150) 27771..28337 + 567 WP_000710385.1 hypothetical protein -
N4Q44_RS19145 (N4Q44_19155) 28386..28568 + 183 WP_000373385.1 hypothetical protein -
N4Q44_RS19150 (N4Q44_19160) 28635..29333 + 699 WP_000873188.1 hypothetical protein -
N4Q44_RS19155 (N4Q44_19165) 29472..29855 + 384 WP_000654348.1 hypothetical protein -
N4Q44_RS19160 (N4Q44_19170) 29922..30680 + 759 WP_001053128.1 hypothetical protein -
N4Q44_RS19165 (N4Q44_19175) 30732..31067 + 336 WP_000653925.1 hypothetical protein -
N4Q44_RS19170 (N4Q44_19180) 31932..32246 + 315 WP_000708715.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..73444 73444


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-109)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-88)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13751.62 Da        Isoelectric Point: 4.8212

>T257499 WP_000312250.1 NZ_CP104296:c27570-27211 [Acinetobacter baumannii]
MAWDVETTELFDSWLAEQDENAQDKILASLLVLSELGPNLGRPHVDTIKESKYPNMKEIRVQVKGHPIRGFFAFDPERKA
IVLCAGDKKGLNEKAFYKEMIKIADEQYEQYLRDNYGDK

Download         Length: 360 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11012.93 Da        Isoelectric Point: 10.4856

>AT257499 WP_001096429.1 NZ_CP104296:c27211-26912 [Acinetobacter baumannii]
MAKLNDIISKRSPESQQRIKKMANQMLLDINLSNLREELKISQAEIAKNLGVSQAAISKREKLGKDLKISSLKEYVEAMG
GKVRLDVELPNGKHVAISI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References