Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3558815..3559472 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N2K86_RS16695 Protein ID WP_260659333.1
Coordinates 3558815..3559114 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2K86_RS16700 Protein ID WP_260659334.1
Coordinates 3559125..3559472 (+) Length 116 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS16685 (N2K86_16685) 3555191..3557383 + 2193 WP_260659332.1 type I secretion system permease/ATPase -
N2K86_RS16690 (N2K86_16690) 3557394..3558563 + 1170 WP_260661710.1 HlyD family efflux transporter periplasmic adaptor subunit -
N2K86_RS16695 (N2K86_16695) 3558815..3559114 + 300 WP_260659333.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2K86_RS16700 (N2K86_16700) 3559125..3559472 + 348 WP_260659334.1 HigA family addiction module antitoxin Antitoxin
N2K86_RS16705 (N2K86_16705) 3559493..3560218 - 726 WP_260659335.1 helix-turn-helix transcriptional regulator -
N2K86_RS16710 (N2K86_16710) 3560315..3560734 + 420 WP_260659336.1 nuclear transport factor 2 family protein -
N2K86_RS16715 (N2K86_16715) 3560742..3561923 - 1182 WP_260659337.1 PLP-dependent aminotransferase family protein -
N2K86_RS16720 (N2K86_16720) 3561944..3562831 - 888 WP_260659338.1 LysR family transcriptional regulator -
N2K86_RS16725 (N2K86_16725) 3562929..3563531 + 603 WP_260659339.1 short chain dehydrogenase -
N2K86_RS16730 (N2K86_16730) 3563525..3564259 - 735 WP_260659340.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11717.28 Da        Isoelectric Point: 9.9488

>T257483 WP_260659333.1 NZ_CP104285:3558815-3559114 [Enterobacter mori]
MINHFRDQWLEDFFLYGRSSNVIPVNLETALARKLDIINSATSHRDLRSPPGNMYEALNPPLKGYSSIRVNRQYRLVFRW
TEGRADDLYLSPHKYTHHK

Download         Length: 300 bp

Antitoxin


Download         Length: 116 a.a.        Molecular weight: 13071.04 Da        Isoelectric Point: 8.5279

>AT257483 WP_260659334.1 NZ_CP104285:3559125-3559472 [Enterobacter mori]
MTLQQALRKPTTPGDVLQYEYLEPLNLKISDLAEMLNVHRNTISALVNNNRKLTADMAIKLAKAFDTTIEFWLNLQLNVD
IWEAQSSSRTQEELSRIKTVADIMAKRKSGRPDVA

Download         Length: 348 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References