Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2947852..2948512 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N2K86_RS13990 Protein ID WP_062935980.1
Coordinates 2948159..2948512 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2K86_RS13985 Protein ID WP_260658989.1
Coordinates 2947852..2948154 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS13960 (N2K86_13960) 2944463..2944795 - 333 WP_260658984.1 type II toxin-antitoxin system PemK/MazF family toxin -
N2K86_RS13965 (N2K86_13965) 2944796..2945053 - 258 WP_260658985.1 antitoxin -
N2K86_RS13970 (N2K86_13970) 2945319..2946278 - 960 WP_260658986.1 zinc-binding alcohol dehydrogenase family protein -
N2K86_RS13975 (N2K86_13975) 2946325..2946714 - 390 WP_260658987.1 RidA family protein -
N2K86_RS13980 (N2K86_13980) 2946856..2947776 + 921 WP_260658988.1 LysR family transcriptional regulator -
N2K86_RS13985 (N2K86_13985) 2947852..2948154 - 303 WP_260658989.1 helix-turn-helix domain-containing protein Antitoxin
N2K86_RS13990 (N2K86_13990) 2948159..2948512 - 354 WP_062935980.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2K86_RS13995 (N2K86_13995) 2948732..2949682 - 951 WP_010432106.1 HTH-type transcriptional regulator Cbl -
N2K86_RS14000 (N2K86_14000) 2949779..2950696 - 918 WP_010432103.1 nitrogen assimilation transcriptional regulator NAC -
N2K86_RS14010 (N2K86_14010) 2951226..2952122 - 897 WP_260658991.1 L,D-transpeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-79)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13492.38 Da        Isoelectric Point: 7.8581

>T257482 WP_062935980.1 NZ_CP104285:c2948512-2948159 [Enterobacter mori]
VWTINTTDRFDRWFTSLDDTDRACVLAALLVLREKGPGLSRPYADTLKGSRHSNMKELRIQSKGDPLRAFFAFDPNRTGI
VLCAGNKVGNEKRFYDEMLLVADLEFTHWLNTLKERE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11064.81 Da        Isoelectric Point: 5.6514

>AT257482 WP_260658989.1 NZ_CP104285:c2948154-2947852 [Enterobacter mori]
MGRTLEQLIADEKPEVVASAEAIATDILLNIHLSELREKVHKTQVEMAQTLGIKQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDVELPDGSHYDFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References