Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 35741..36471 Replicon chromosome
Accession NZ_CP104285
Organism Enterobacter mori strain JT.W3M11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N2K86_RS00170 Protein ID WP_260660055.1
Coordinates 35741..36055 (+) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2K86_RS00175 Protein ID WP_260660056.1
Coordinates 36052..36471 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K86_RS00145 (N2K86_00145) 31404..32492 + 1089 WP_260660051.1 cellulase family glycosylhydrolase -
N2K86_RS00150 (N2K86_00150) 32395..33579 - 1185 WP_260660052.1 multidrug efflux MFS transporter EmrD -
N2K86_RS00155 (N2K86_00155) 33755..34588 - 834 WP_260660053.1 DMT family transporter -
N2K86_RS00160 (N2K86_00160) 34651..35097 - 447 WP_260660054.1 GNAT family N-acetyltransferase -
N2K86_RS00165 (N2K86_00165) 35162..35251 - 90 WP_045260836.1 type I toxin-antitoxin system toxin TisB -
N2K86_RS00170 (N2K86_00170) 35741..36055 + 315 WP_260660055.1 type II toxin-antitoxin system HigB family toxin Toxin
N2K86_RS00175 (N2K86_00175) 36052..36471 + 420 WP_260660056.1 helix-turn-helix domain-containing protein Antitoxin
N2K86_RS00180 (N2K86_00180) 36619..36717 + 99 WP_057979964.1 ilvB operon leader peptide IvbL -
N2K86_RS00185 (N2K86_00185) 36824..38512 + 1689 WP_260660057.1 acetolactate synthase large subunit -
N2K86_RS00190 (N2K86_00190) 38516..38803 + 288 WP_010426528.1 acetolactate synthase small subunit -
N2K86_RS00195 (N2K86_00195) 39569..40750 + 1182 WP_260660058.1 MFS transporter -
N2K86_RS00200 (N2K86_00200) 40725..41471 + 747 WP_260660059.1 ferritin-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 35162..44417 9255


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-136)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 12383.53 Da        Isoelectric Point: 10.2219

>T257473 WP_260660055.1 NZ_CP104285:35741-36055 [Enterobacter mori]
MHLISLKAIIDAVKQFPQHKEELLFLGRTIEKSHCPTPAALKQIFPTLDNFKYLDKHYVIDIANNILRVVALIFFESQKF
YVRHVFTHKEYDRFTEKHRTKGKK

Download         Length: 315 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15536.08 Da        Isoelectric Point: 4.9440

>AT257473 WP_260660056.1 NZ_CP104285:36052-36471 [Enterobacter mori]
MMIVADAMKATHALVEAVPLLGEHPNEKDYQDALELVEYLLMNEPGSPLLDIVCARISRYEANRPDIVALRQEMESVPVG
IAVLRTLMDQYKLTISDFQDEIGSKSMVSRVLNGQRQLTLNHIKKLAARFGVSPALFIE

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References