Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3441896..3442571 Replicon chromosome
Accession NZ_CP104284
Organism Enterobacter hormaechei subsp. steigerwaltii strain JT.WLB1A

Toxin (Protein)


Gene name higB Uniprot ID A0A837FDC1
Locus tag N2K85_RS16080 Protein ID WP_015571638.1
Coordinates 3441896..3442195 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2K85_RS16085 Protein ID WP_260673206.1
Coordinates 3442206..3442571 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2K85_RS16070 (N2K85_16070) 3438273..3440465 + 2193 WP_039269968.1 type I secretion system permease/ATPase -
N2K85_RS16075 (N2K85_16075) 3440446..3441645 + 1200 WP_017382757.1 HlyD family efflux transporter periplasmic adaptor subunit -
N2K85_RS16080 (N2K85_16080) 3441896..3442195 + 300 WP_015571638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N2K85_RS16085 (N2K85_16085) 3442206..3442571 + 366 WP_260673206.1 HigA family addiction module antitoxin Antitoxin
N2K85_RS16090 (N2K85_16090) 3442598..3443779 - 1182 WP_017382758.1 PLP-dependent aminotransferase family protein -
N2K85_RS16095 (N2K85_16095) 3443800..3444687 - 888 WP_015571641.1 LysR family transcriptional regulator -
N2K85_RS16100 (N2K85_16100) 3444785..3445387 + 603 WP_015571642.1 short chain dehydrogenase -
N2K85_RS16105 (N2K85_16105) 3445381..3446115 - 735 WP_017692800.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11624.29 Da        Isoelectric Point: 9.6776

>T257469 WP_015571638.1 NZ_CP104284:3441896-3442195 [Enterobacter hormaechei subsp. steigerwaltii]
MINHFRDQWLEDFFLYGRSSNVIPLNLETALARKLDIINAAMSHLDLRSPPGNMYEALSPPLKGYSSIRVNRQYRLVFRW
SEGKADDLYLSPHKYTQHK

Download         Length: 300 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13647.70 Da        Isoelectric Point: 9.9629

>AT257469 WP_260673206.1 NZ_CP104284:3442206-3442571 [Enterobacter hormaechei subsp. steigerwaltii]
MTLQQALRKPTTPGEVLQYEYLAPLNLKINDLAEMLNVHRNTVSALVNNNRKLTADMAIKLAKAFNTTIEFWLNLQLNVD
IWEAQSNSRTQEELSRIKTVAEVMAKRKSGKPDVTLHGNSA

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FDC1

Antitoxin

Source ID Structure

References