Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4768643..4769245 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag N2O69_RS23310 Protein ID WP_000897302.1
Coordinates 4768934..4769245 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N2O69_RS23305 Protein ID WP_000356397.1
Coordinates 4768643..4768933 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS23280 (4764716) 4764716..4765618 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N2O69_RS23285 (4765615) 4765615..4766250 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N2O69_RS23290 (4766247) 4766247..4767176 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
N2O69_RS23295 (4767392) 4767392..4767610 - 219 WP_001314326.1 CopG family transcriptional regulator -
N2O69_RS23300 (4768006) 4768006..4768284 - 279 WP_001296612.1 hypothetical protein -
N2O69_RS23305 (4768643) 4768643..4768933 - 291 WP_000356397.1 NadS family protein Antitoxin
N2O69_RS23310 (4768934) 4768934..4769245 - 312 WP_000897302.1 hypothetical protein Toxin
N2O69_RS23315 (4769474) 4769474..4770382 + 909 WP_001774092.1 alpha/beta hydrolase -
N2O69_RS23320 (4770446) 4770446..4771387 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N2O69_RS23325 (4771432) 4771432..4771869 - 438 WP_000560978.1 D-aminoacyl-tRNA deacylase -
N2O69_RS23330 (4771866) 4771866..4772738 - 873 WP_000920762.1 virulence factor BrkB family protein -
N2O69_RS23335 (4772732) 4772732..4773331 - 600 WP_001314324.1 glucose-1-phosphatase -
N2O69_RS23340 (4773430) 4773430..4774215 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T257456 WP_000897302.1 NZ_CP104274:c4769245-4768934 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT257456 WP_000356397.1 NZ_CP104274:c4768933-4768643 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References