Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1901680..1902182 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag N2O69_RS09025 Protein ID WP_000767822.1
Coordinates 1901928..1902182 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N2O69_RS09020 Protein ID WP_001259255.1
Coordinates 1901680..1901931 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS08995 (1896858) 1896858..1897925 - 1068 WP_001538920.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N2O69_RS09000 (1897925) 1897925..1898995 - 1071 WP_001538918.1 histidinol-phosphate transaminase -
N2O69_RS09005 (1898992) 1898992..1900296 - 1305 WP_001445483.1 histidinol dehydrogenase -
N2O69_RS09010 (1900302) 1900302..1901201 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
N2O69_RS09015 (1901347) 1901347..1901397 - 51 WP_001364200.1 his operon leader peptide -
N2O69_RS09020 (1901680) 1901680..1901931 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N2O69_RS09025 (1901928) 1901928..1902182 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N2O69_RS09030 (1902265) 1902265..1903089 + 825 WP_000754737.1 SDR family oxidoreductase -
N2O69_RS09035 (1903135) 1903135..1904064 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
N2O69_RS09040 (1904279) 1904279..1904341 + 63 WP_010723108.1 membrane protein YoeI -
N2O69_RS09045 (1904331) 1904331..1905689 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257438 WP_000767822.1 NZ_CP104274:1901928-1902182 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257438 WP_001259255.1 NZ_CP104274:1901680-1901931 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References