257435

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 726763..727456 Replicon chromosome
Accession NZ_CP104274
Organism Escherichia coli strain Ec15103

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N2O69_RS03530 Protein ID WP_000415584.1
Coordinates 726763..727059 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N2O69_RS03535 Protein ID WP_000650107.1
Coordinates 727061..727456 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N2O69_RS03495 (721851) 721851..722165 - 315 WP_000958598.1 putative quinol monooxygenase -
N2O69_RS03500 (722196) 722196..722777 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N2O69_RS03505 (723096) 723096..723428 + 333 WP_000917685.1 DUF2645 family protein -
N2O69_RS03510 (723474) 723474..724823 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N2O69_RS03515 (724820) 724820..725479 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N2O69_RS03520 (725631) 725631..726023 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N2O69_RS03525 (726076) 726076..726558 + 483 WP_000183505.1 GyrI-like domain-containing protein -
N2O69_RS03530 (726763) 726763..727059 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N2O69_RS03535 (727061) 727061..727456 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N2O69_RS03540 (727589) 727589..729196 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N2O69_RS03545 (729334) 729334..731592 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T257435 WP_000415584.1 NZ_CP104274:726763-727059 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT257435 WP_000650107.1 NZ_CP104274:727061-727456 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LU65

References