Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5608912..5609507 Replicon chromosome
Accession NZ_CP104254
Organism Pseudomonas aeruginosa strain PALA1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PALA1_RS26620 Protein ID WP_003113526.1
Coordinates 5609229..5609507 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag PALA1_RS26615 Protein ID WP_003111575.1
Coordinates 5608912..5609217 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PALA1_RS26580 (PALA1_05246) 5604064..5604912 + 849 WP_009878189.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PALA1_RS26590 (PALA1_05248) 5605079..5606020 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PALA1_RS26595 (PALA1_05249) 5606137..5606751 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PALA1_RS26600 (PALA1_05250) 5606792..5607376 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PALA1_RS26605 (PALA1_05251) 5607417..5608517 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PALA1_RS26615 (PALA1_05253) 5608912..5609217 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
PALA1_RS26620 5609229..5609507 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PALA1_RS26625 5609560..5609688 - 129 Protein_5262 integrase -
PALA1_RS26630 (PALA1_05254) 5609836..5612064 + 2229 WP_021264080.1 TonB-dependent receptor -
PALA1_RS26635 (PALA1_05255) 5612134..5612781 - 648 WP_003095021.1 carbonate dehydratase -
PALA1_RS26640 (PALA1_05256) 5612843..5614081 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T257432 WP_003113526.1 NZ_CP104254:c5609507-5609229 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT257432 WP_003111575.1 NZ_CP104254:c5609217-5608912 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References