Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 3318042..3318662 Replicon chromosome
Accession NZ_CP104215
Organism Burkholderia gladioli strain ZN-S4

Toxin (Protein)


Gene name higB Uniprot ID A0A838CB01
Locus tag NYZ96_RS32580 Protein ID WP_046574672.1
Coordinates 3318384..3318662 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A560VTG3
Locus tag NYZ96_RS32575 Protein ID WP_029951048.1
Coordinates 3318042..3318365 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYZ96_RS32555 (NYZ96_32555) 3313772..3314185 - 414 WP_013690200.1 MarR family transcriptional regulator -
NYZ96_RS32560 (NYZ96_32560) 3314293..3315480 - 1188 WP_260531665.1 HPP family protein -
NYZ96_RS32565 (NYZ96_32565) 3315873..3316829 + 957 WP_025100402.1 LysR family transcriptional regulator -
NYZ96_RS32570 (NYZ96_32570) 3316849..3317934 - 1086 WP_025100403.1 ionic transporter y4hA -
NYZ96_RS32575 (NYZ96_32575) 3318042..3318365 - 324 WP_029951048.1 HigA family addiction module antitoxin Antitoxin
NYZ96_RS32580 (NYZ96_32580) 3318384..3318662 - 279 WP_046574672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYZ96_RS32585 (NYZ96_32585) 3318906..3319574 + 669 WP_025100406.1 MarC family protein -
NYZ96_RS32590 (NYZ96_32590) 3319692..3320561 - 870 WP_126241135.1 CPBP family intramembrane metalloprotease -
NYZ96_RS32595 (NYZ96_32595) 3320835..3321557 - 723 WP_046574677.1 fumarylacetoacetate hydrolase family protein -
NYZ96_RS32600 (NYZ96_32600) 3321706..3322806 - 1101 WP_105848813.1 helix-turn-helix transcriptional regulator -
NYZ96_RS32605 (NYZ96_32605) 3322999..3323601 - 603 WP_013690210.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(13-88)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10401.00 Da        Isoelectric Point: 9.9309

>T257423 WP_046574672.1 NZ_CP104215:c3318662-3318384 [Burkholderia gladioli]
MIQSFRCKRTAALFAGESPPAWRAVAQVARRKLAMLDAAQALRDLAVPPGNQLEGLFGDRAGQYSIRINERWRLCFVWSS
RGPELVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11903.72 Da        Isoelectric Point: 7.2024

>AT257423 WP_029951048.1 NZ_CP104215:c3318365-3318042 [Burkholderia gladioli]
MNAKSVKPVNAMPAIHPGEILREEFLVPLALSVNALSLALMVPATRMHEIVNERRGITADTAYRLSRYFGTTPEFWLALQ
ADYDIKTLPNRDEIDRKVDARPNGAAA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A838CB01

Antitoxin

Source ID Structure
AlphaFold DB A0A560VTG3

References