257415

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4658013..4658615 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag N1H45_RS22680 Protein ID WP_000897305.1
Coordinates 4658304..4658615 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1H45_RS22675 Protein ID WP_000356397.1
Coordinates 4658013..4658303 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS22650 (4653939) 4653939..4654841 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
N1H45_RS22655 (4654838) 4654838..4655473 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
N1H45_RS22660 (4655470) 4655470..4656399 + 930 WP_000027702.1 formate dehydrogenase accessory protein FdhE -
N1H45_RS22665 (4656729) 4656729..4656971 - 243 WP_001086388.1 protein YiiF -
N1H45_RS22670 (4657190) 4657190..4657408 - 219 WP_001295676.1 CopG family transcriptional regulator -
N1H45_RS22675 (4658013) 4658013..4658303 - 291 WP_000356397.1 NadS family protein Antitoxin
N1H45_RS22680 (4658304) 4658304..4658615 - 312 WP_000897305.1 hypothetical protein Toxin
N1H45_RS22685 (4658844) 4658844..4659752 + 909 WP_001162704.1 alpha/beta hydrolase -
N1H45_RS22690 (4659816) 4659816..4660757 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
N1H45_RS22695 (4660802) 4660802..4661239 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
N1H45_RS22700 (4661236) 4661236..4662108 - 873 WP_000920762.1 virulence factor BrkB family protein -
N1H45_RS22705 (4662102) 4662102..4662701 - 600 WP_001315111.1 glucose-1-phosphatase -
N1H45_RS22710 (4662800) 4662800..4663585 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T257415 WP_000897305.1 NZ_CP104206:c4658615-4658304 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT257415 WP_000356397.1 NZ_CP104206:c4658303-4658013 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References