Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3694167..3694708 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name yafQ Uniprot ID U9XPG0
Locus tag N1H45_RS18175 Protein ID WP_000615976.1
Coordinates 3694430..3694708 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag N1H45_RS18170 Protein ID WP_000729704.1
Coordinates 3694167..3694427 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS18145 (3689203) 3689203..3690342 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
N1H45_RS18150 (3690326) 3690326..3692419 + 2094 WP_001140808.1 flagellar biosynthesis protein FlhA -
N1H45_RS18155 (3692524) 3692524..3692802 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
N1H45_RS18160 (3692795) 3692795..3693151 + 357 WP_001030483.1 type II toxin-antitoxin system HicB family antitoxin -
N1H45_RS18165 (3693208) 3693208..3693981 - 774 WP_000543895.1 C40 family peptidase -
N1H45_RS18170 (3694167) 3694167..3694427 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N1H45_RS18175 (3694430) 3694430..3694708 + 279 WP_000615976.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N1H45_RS18180 (3694864) 3694864..3695604 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N1H45_RS18185 (3695575) 3695575..3696342 - 768 WP_000333380.1 class II glutamine amidotransferase -
N1H45_RS18190 (3696548) 3696548..3697126 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - gmhA/lpcA 3692795..3703736 10941


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10800.59 Da        Isoelectric Point: 10.0702

>T257411 WP_000615976.1 NZ_CP104206:3694430-3694708 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNALPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT257411 WP_000729704.1 NZ_CP104206:3694167-3694427 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XPG0

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References