257393

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 622186..622985 Replicon chromosome
Accession NZ_CP104206
Organism Escherichia coli strain hubt-sl

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag N1H45_RS03055 Protein ID WP_000347267.1
Coordinates 622186..622650 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag N1H45_RS03060 Protein ID WP_001307405.1
Coordinates 622650..622985 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1H45_RS03025 (617187) 617187..617621 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
N1H45_RS03030 (617639) 617639..618517 - 879 WP_001298758.1 PTS N-acetylgalactosamine transporter subunit IID -
N1H45_RS03035 (618507) 618507..619286 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
N1H45_RS03040 (619297) 619297..619770 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
N1H45_RS03045 (619793) 619793..621073 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
N1H45_RS03050 (621322) 621322..622131 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
N1H45_RS03055 (622186) 622186..622650 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
N1H45_RS03060 (622650) 622650..622985 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
N1H45_RS03065 (623134) 623134..624705 - 1572 WP_001273741.1 galactarate dehydratase -
N1H45_RS03070 (625080) 625080..626414 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
N1H45_RS03075 (626430) 626430..627200 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T257393 WP_000347267.1 NZ_CP104206:c622650-622186 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT257393 WP_001307405.1 NZ_CP104206:c622985-622650 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References