257364

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 4871382..4871977 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag NDR95_RS22860 Protein ID WP_003117425.1
Coordinates 4871699..4871977 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDR95_RS22855 Protein ID WP_003099268.1
Coordinates 4871382..4871687 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS22820 (NDR95_22820) 4866523..4867371 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
NDR95_RS22830 (NDR95_22830) 4867538..4868479 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
NDR95_RS22835 (NDR95_22835) 4868596..4869210 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
NDR95_RS22840 (NDR95_22840) 4869252..4869836 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
NDR95_RS22845 (NDR95_22845) 4869877..4870977 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
NDR95_RS22855 (NDR95_22855) 4871382..4871687 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
NDR95_RS22860 (NDR95_22860) 4871699..4871977 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDR95_RS22865 (NDR95_22865) 4872030..4872158 - 129 Protein_4511 integrase -
NDR95_RS22870 (NDR95_22870) 4872306..4874534 + 2229 WP_119565521.1 TonB-dependent receptor -
NDR95_RS22875 (NDR95_22875) 4874604..4875251 - 648 WP_003095021.1 carbonate dehydratase -
NDR95_RS22880 (NDR95_22880) 4875313..4876551 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T257364 WP_003117425.1 NZ_CP104170:c4871977-4871699 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT257364 WP_003099268.1 NZ_CP104170:c4871687-4871382 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References