257362

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4164280..4164961 Replicon chromosome
Accession NZ_CP104170
Organism Pseudomonas aeruginosa strain HW001G

Toxin (Protein)


Gene name higB Uniprot ID V6AKP0
Locus tag NDR95_RS19550 Protein ID WP_003111825.1
Coordinates 4164596..4164961 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NDR95_RS19545 Protein ID WP_023112790.1
Coordinates 4164280..4164603 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDR95_RS19525 (NDR95_19525) 4159733..4161406 + 1674 WP_128652968.1 hypothetical protein -
NDR95_RS19530 (NDR95_19530) 4161403..4162110 + 708 WP_119565573.1 DUF3800 domain-containing protein -
NDR95_RS19535 (NDR95_19535) 4162107..4162592 + 486 WP_058160013.1 hypothetical protein -
NDR95_RS19545 (NDR95_19545) 4164280..4164603 - 324 WP_023112790.1 XRE family transcriptional regulator Antitoxin
NDR95_RS19550 (NDR95_19550) 4164596..4164961 - 366 WP_003111825.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NDR95_RS19555 (NDR95_19555) 4165253..4165427 - 175 Protein_3864 hypothetical protein -
NDR95_RS19560 (NDR95_19560) 4165634..4165906 + 273 WP_031805311.1 hypothetical protein -
NDR95_RS19565 (NDR95_19565) 4165937..4166362 - 426 WP_003140891.1 VOC family protein -
NDR95_RS19570 (NDR95_19570) 4166463..4167347 + 885 WP_031805310.1 LysR substrate-binding domain-containing protein -
NDR95_RS19575 (NDR95_19575) 4167320..4168273 - 954 WP_003085661.1 LysR substrate-binding domain-containing protein -
NDR95_RS19580 (NDR95_19580) 4168494..4168928 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4149769..4167347 17578


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-63)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13880.24 Da        Isoelectric Point: 4.8219

>T257362 WP_003111825.1 NZ_CP104170:c4164961-4164596 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRHGHMRELRTQHGGRPFRTLYAFDPRRSA
ILLIGGDKTGDDRWYELNVPIADRLYDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11873.69 Da        Isoelectric Point: 5.8900

>AT257362 WP_023112790.1 NZ_CP104170:c4164603-4164280 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEGQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GQLEVIARFPDGAVKISNFADIEEAGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6AKP0

Antitoxin

Source ID Structure

References