257316

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2652021..2652639 Replicon plasmid pC101a
Accession NZ_CP104135
Organism Sinorhizobium sp. C101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N0R80_RS15610 Protein ID WP_275597441.1
Coordinates 2652343..2652639 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N0R80_RS15605 Protein ID WP_100671964.1
Coordinates 2652021..2652329 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0R80_RS15580 (N0R80_15580) 2647337..2648320 + 984 WP_018095868.1 ABC transporter ATP-binding protein -
N0R80_RS15585 (N0R80_15585) 2648317..2649321 + 1005 WP_275597443.1 ABC transporter ATP-binding protein -
N0R80_RS15590 (N0R80_15590) 2649402..2650079 - 678 WP_018095870.1 GntR family transcriptional regulator -
N0R80_RS15595 (N0R80_15595) 2650214..2650837 + 624 WP_018095871.1 flavin reductase family protein -
N0R80_RS15600 (N0R80_15600) 2650869..2651594 + 726 WP_275597442.1 aspartate/glutamate racemase family protein -
N0R80_RS15605 (N0R80_15605) 2652021..2652329 - 309 WP_100671964.1 HigA family addiction module antitoxin Antitoxin
N0R80_RS15610 (N0R80_15610) 2652343..2652639 - 297 WP_275597441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0R80_RS15615 (N0R80_15615) 2652884..2653864 - 981 WP_275597440.1 LysR family transcriptional regulator -
N0R80_RS15620 (N0R80_15620) 2653970..2654934 + 965 Protein_2532 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / adeG / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521547 3521547


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11686.09 Da        Isoelectric Point: 5.6246

>T257316 WP_275597441.1 NZ_CP104135:c2652639-2652343 [Sinorhizobium sp. C101]
MIVGFRDDWLRAFFVDDAHSRNIPSDLEVRLFRKLQMIDDATTDQDLRVPPSNFFEKLRGNLAGFHSIRVNQQWRLIFRW
DGERGEADGIYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11585.39 Da        Isoelectric Point: 10.5795

>AT257316 WP_100671964.1 NZ_CP104135:c2652329-2652021 [Sinorhizobium sp. C101]
MLTTKRKPATVGEILTEEFMEPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
EVMNTPKERERVERARPLKHAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References