Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 425689..426307 Replicon plasmid pK101a
Accession NZ_CP104131
Organism Sinorhizobium sp. K101

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N0Q91_RS04670 Protein ID WP_275597441.1
Coordinates 425689..425985 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N0Q91_RS04675 Protein ID WP_100671964.1
Coordinates 425999..426307 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q91_RS04660 (N0Q91_04660) 423394..424358 - 965 Protein_378 MBL fold metallo-hydrolase -
N0Q91_RS04665 (N0Q91_04665) 424464..425444 + 981 WP_275597440.1 LysR family transcriptional regulator -
N0Q91_RS04670 (N0Q91_04670) 425689..425985 + 297 WP_275597441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0Q91_RS04675 (N0Q91_04675) 425999..426307 + 309 WP_100671964.1 HigA family addiction module antitoxin Antitoxin
N0Q91_RS04680 (N0Q91_04680) 426733..427458 - 726 WP_275597442.1 aspartate/glutamate racemase family protein -
N0Q91_RS04685 (N0Q91_04685) 427490..428113 - 624 WP_018095871.1 flavin reductase family protein -
N0Q91_RS04690 (N0Q91_04690) 428248..428925 + 678 WP_018095870.1 GntR family transcriptional regulator -
N0Q91_RS04695 (N0Q91_04695) 429006..430010 - 1005 WP_275597443.1 ABC transporter ATP-binding protein -
N0Q91_RS04700 (N0Q91_04700) 430007..430990 - 984 WP_018095868.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pgm / acpXL / kdsA / tufA / tufA / acpXL / htpB / icl / fliQ / adeG / kdsB 1..3521393 3521393


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11686.09 Da        Isoelectric Point: 5.6246

>T257300 WP_275597441.1 NZ_CP104131:425689-425985 [Sinorhizobium sp. K101]
MIVGFRDDWLRAFFVDDAHSRNIPSDLEVRLFRKLQMIDDATTDQDLRVPPSNFFEKLRGNLAGFHSIRVNQQWRLIFRW
DGERGEADGIYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11585.39 Da        Isoelectric Point: 10.5795

>AT257300 WP_100671964.1 NZ_CP104131:425999-426307 [Sinorhizobium sp. K101]
MLTTKRKPATVGEILTEEFMEPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
EVMNTPKERERVERARPLKHAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References