257290

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2651994..2652612 Replicon plasmid pM103a
Accession NZ_CP104127
Organism Sinorhizobium sp. M103

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N0Q90_RS15635 Protein ID WP_275597441.1
Coordinates 2652316..2652612 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N0Q90_RS15630 Protein ID WP_100671964.1
Coordinates 2651994..2652302 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0Q90_RS15605 (N0Q90_15605) 2647309..2648293 + 985 Protein_2524 ABC transporter ATP-binding protein -
N0Q90_RS15610 (N0Q90_15610) 2648290..2649294 + 1005 WP_275597443.1 ABC transporter ATP-binding protein -
N0Q90_RS15615 (N0Q90_15615) 2649375..2650052 - 678 WP_018095870.1 GntR family transcriptional regulator -
N0Q90_RS15620 (N0Q90_15620) 2650187..2650810 + 624 WP_018095871.1 flavin reductase family protein -
N0Q90_RS15625 (N0Q90_15625) 2650842..2651567 + 726 WP_275597442.1 aspartate/glutamate racemase family protein -
N0Q90_RS15630 (N0Q90_15630) 2651994..2652302 - 309 WP_100671964.1 HigA family addiction module antitoxin Antitoxin
N0Q90_RS15635 (N0Q90_15635) 2652316..2652612 - 297 WP_275597441.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0Q90_RS15640 (N0Q90_15640) 2652857..2653837 - 981 WP_275597440.1 LysR family transcriptional regulator -
N0Q90_RS15645 (N0Q90_15645) 2653943..2654907 + 965 Protein_2532 MBL fold metallo-hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - kdsB / adeG / fliE / fliQ / flhA / icl / htpB / acpXL / tufA / tufA / kdsA / acpXL / pgm 1..3521513 3521513


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11686.09 Da        Isoelectric Point: 5.6246

>T257290 WP_275597441.1 NZ_CP104127:c2652612-2652316 [Sinorhizobium sp. M103]
MIVGFRDDWLRAFFVDDAHSRNIPSDLEVRLFRKLQMIDDATTDQDLRVPPSNFFEKLRGNLAGFHSIRVNQQWRLIFRW
DGERGEADGIYLDDHSYR

Download         Length: 297 bp

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11585.39 Da        Isoelectric Point: 10.5795

>AT257290 WP_100671964.1 NZ_CP104127:c2652302-2651994 [Sinorhizobium sp. M103]
MLTTKRKPATVGEILTEEFMEPMGLTQGALAEAMGVQRKHVNELCGNRRNVTAATALILARVFGNSPDFWLNVQRRNDLW
EVMNTPKERERVERARPLKHAA

Download         Length: 309 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References