257281

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3741874..3742415 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name yafQ Uniprot ID S1FHQ9
Locus tag N1705_RS18035 Protein ID WP_000615979.1
Coordinates 3742137..3742415 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag N1705_RS18030 Protein ID WP_000729704.1
Coordinates 3741874..3742134 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS18005 (3737657) 3737657..3738442 - 786 WP_000207568.1 putative lateral flagellar export/assembly protein LafU -
N1705_RS18010 (3738414) 3738414..3740126 + 1713 Protein_3526 flagellar biosynthesis protein FlhA -
N1705_RS18015 (3740231) 3740231..3740509 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
N1705_RS18020 (3740502) 3740502..3740858 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
N1705_RS18025 (3740915) 3740915..3741688 - 774 WP_000543899.1 C40 family peptidase -
N1705_RS18030 (3741874) 3741874..3742134 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
N1705_RS18035 (3742137) 3742137..3742415 + 279 WP_000615979.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
N1705_RS18040 (3742571) 3742571..3743311 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
N1705_RS18045 (3743282) 3743282..3744049 - 768 WP_001365365.1 class II glutamine amidotransferase -
N1705_RS18050 (3744255) 3744255..3744833 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10830.62 Da        Isoelectric Point: 10.0702

>T257281 WP_000615979.1 NZ_CP104123:3742137-3742415 [Escherichia coli]
MIQRDIEYSGQFSKDVKLAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT257281 WP_000729704.1 NZ_CP104123:3741874-3742134 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1FHQ9

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0Y6Z6

References