257271

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1932588..1933090 Replicon chromosome
Accession NZ_CP104123
Organism Escherichia coli strain USDA-ARS-USMARC-49610

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N1705_RS09220 Protein ID WP_000767829.1
Coordinates 1932836..1933090 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID E2QNP3
Locus tag N1705_RS09215 Protein ID WP_001259253.1
Coordinates 1932588..1932839 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1705_RS09190 (1927766) 1927766..1928833 - 1068 WP_000080093.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
N1705_RS09195 (1928833) 1928833..1929903 - 1071 WP_000108967.1 histidinol-phosphate transaminase -
N1705_RS09200 (1929900) 1929900..1931204 - 1305 WP_021562654.1 histidinol dehydrogenase -
N1705_RS09205 (1931210) 1931210..1932109 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
N1705_RS09210 (1932255) 1932255..1932305 - 51 WP_001364200.1 his operon leader peptide -
N1705_RS09215 (1932588) 1932588..1932839 + 252 WP_001259253.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N1705_RS09220 (1932836) 1932836..1933090 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N1705_RS09225 (1933173) 1933173..1933997 + 825 WP_000754758.1 SDR family oxidoreductase -
N1705_RS09230 (1934043) 1934043..1934972 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N1705_RS09235 (1935187) 1935187..1935249 + 63 WP_010723108.1 membrane protein YoeI -
N1705_RS09240 (1935239) 1935239..1936597 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N1705_RS09245 (1936774) 1936774..1937832 + 1059 WP_024193414.1 thiosulfate utilization transporter TsuA/YeeE -
N1705_RS09250 (1937846) 1937846..1938073 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257271 WP_000767829.1 NZ_CP104123:1932836-1933090 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9365.62 Da        Isoelectric Point: 4.6127

>AT257271 WP_001259253.1 NZ_CP104123:1932588-1932839 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSDKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB E2QNP3

References