Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3950916..3951609 Replicon chromosome
Accession NZ_CP104114
Organism Escherichia coli strain USDA-ARS-USMARC-51408

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag N1706_RS19005 Protein ID WP_000415584.1
Coordinates 3951313..3951609 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag N1706_RS19000 Protein ID WP_000650107.1
Coordinates 3950916..3951311 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1706_RS18990 (3946780) 3946780..3949038 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
N1706_RS18995 (3949176) 3949176..3950783 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
N1706_RS19000 (3950916) 3950916..3951311 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
N1706_RS19005 (3951313) 3951313..3951609 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
N1706_RS19010 (3951814) 3951814..3952296 - 483 WP_000183505.1 GyrI-like domain-containing protein -
N1706_RS19015 (3952349) 3952349..3952741 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
N1706_RS19020 (3952893) 3952893..3953552 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
N1706_RS19025 (3953549) 3953549..3954898 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
N1706_RS19030 (3954944) 3954944..3955276 - 333 WP_000917684.1 DUF2645 family protein -
N1706_RS19035 (3955595) 3955595..3956176 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
N1706_RS19040 (3956207) 3956207..3956521 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T257233 WP_000415584.1 NZ_CP104114:c3951609-3951313 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT257233 WP_000650107.1 NZ_CP104114:c3951311-3950916 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References