257230

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 2864943..2865445 Replicon chromosome
Accession NZ_CP104114
Organism Escherichia coli strain USDA-ARS-USMARC-51408

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag N1706_RS14010 Protein ID WP_000767829.1
Coordinates 2864943..2865197 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag N1706_RS14015 Protein ID WP_001259255.1
Coordinates 2865194..2865445 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1706_RS13980 (2859968) 2859968..2860195 - 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -
N1706_RS13985 (2860209) 2860209..2861267 - 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
N1706_RS13990 (2861436) 2861436..2862794 - 1359 WP_000019197.1 putrescine/proton symporter PlaP -
N1706_RS13995 (2862784) 2862784..2862846 - 63 WP_010723108.1 membrane protein YoeI -
N1706_RS14000 (2863061) 2863061..2863990 - 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
N1706_RS14005 (2864036) 2864036..2864860 - 825 WP_000754749.1 SDR family oxidoreductase -
N1706_RS14010 (2864943) 2864943..2865197 - 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
N1706_RS14015 (2865194) 2865194..2865445 - 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
N1706_RS14020 (2865728) 2865728..2865778 + 51 WP_001364200.1 his operon leader peptide -
N1706_RS14025 (2865924) 2865924..2866823 + 900 WP_000131777.1 ATP phosphoribosyltransferase -
N1706_RS14030 (2866829) 2866829..2868133 + 1305 WP_001614652.1 histidinol dehydrogenase -
N1706_RS14035 (2868130) 2868130..2869200 + 1071 WP_000108961.1 histidinol-phosphate transaminase -
N1706_RS14040 (2869200) 2869200..2870267 + 1068 WP_000080066.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T257230 WP_000767829.1 NZ_CP104114:c2865197-2864943 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT257230 WP_001259255.1 NZ_CP104114:c2865445-2865194 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References