Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2233477..2234115 Replicon chromosome
Accession NZ_CP104114
Organism Escherichia coli strain USDA-ARS-USMARC-51408

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag N1706_RS10760 Protein ID WP_000813794.1
Coordinates 2233477..2233653 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag N1706_RS10765 Protein ID WP_001270286.1
Coordinates 2233699..2234115 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1706_RS10740 (2229096) 2229096..2230310 - 1215 WP_001326689.1 BenE family transporter YdcO -
N1706_RS10745 (2230363) 2230363..2230899 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
N1706_RS10750 (2230972) 2230972..2232933 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
N1706_RS10755 (2233025) 2233025..2233255 - 231 WP_000494244.1 YncJ family protein -
N1706_RS10760 (2233477) 2233477..2233653 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
N1706_RS10765 (2233699) 2233699..2234115 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
N1706_RS10770 (2234194) 2234194..2235600 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
N1706_RS10775 (2235845) 2235845..2236990 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
N1706_RS10780 (2237008) 2237008..2238021 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
N1706_RS10785 (2238022) 2238022..2238963 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2227908..2229056 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T257223 WP_000813794.1 NZ_CP104114:2233477-2233653 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT257223 WP_001270286.1 NZ_CP104114:2233699-2234115 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References