Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 647085..647497 Replicon chromosome
Accession NZ_CP104114
Organism Escherichia coli strain USDA-ARS-USMARC-51408

Toxin (Protein)


Gene name symE Uniprot ID A0A0B1K116
Locus tag N1706_RS03035 Protein ID WP_000132623.1
Coordinates 647085..647426 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 647421..647497 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1706_RS03015 (643094) 643094..644506 - 1413 WP_032304527.1 PLP-dependent aminotransferase family protein -
N1706_RS03020 (644683) 644683..644847 + 165 WP_000394278.1 DUF1127 domain-containing protein -
N1706_RS03025 (644945) 644945..645827 + 883 Protein_572 DUF262 domain-containing protein -
N1706_RS03030 (645875) 645875..647038 + 1164 WP_071940936.1 DUF1524 domain-containing protein -
N1706_RS03035 (647085) 647085..647426 - 342 WP_000132623.1 endoribonuclease SymE Toxin
- (647421) 647421..647497 + 77 NuclAT_27 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_27 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_27 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_27 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_28 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_28 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_28 - Antitoxin
- (647421) 647421..647497 + 77 NuclAT_28 - Antitoxin
N1706_RS03040 (647641) 647641..650904 - 3264 WP_000058876.1 HsdR family type I site-specific deoxyribonuclease -
N1706_RS03045 (650999) 650999..652396 - 1398 WP_260223208.1 restriction endonuclease subunit S -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12323.21 Da        Isoelectric Point: 9.5818

>T257218 WP_000132623.1 NZ_CP104114:c647426-647085 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMKGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVREFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT257218 NZ_CP104114:647421-647497 [Escherichia coli]
AGTCATAACTGCTATTCTCCGATAATAGTGATTGTGATTAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B1K116

Antitoxin

Download structure file

References