Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4092364..4092965 Replicon chromosome
Accession NZ_CP104108
Organism Cronobacter sakazakii strain USDA-ARS-USMARC-54664

Toxin (Protein)


Gene name higB Uniprot ID A0A855WMY7
Locus tag N1710_RS19200 Protein ID WP_054623952.1
Coordinates 4092654..4092965 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1710_RS19195 Protein ID WP_007871962.1
Coordinates 4092364..4092654 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1710_RS19180 (N1710_19180) 4089830..4090732 + 903 WP_004385164.1 formate dehydrogenase subunit beta -
N1710_RS19185 (N1710_19185) 4090729..4091364 + 636 WP_004385165.1 formate dehydrogenase cytochrome b556 subunit -
N1710_RS19190 (N1710_19190) 4091361..4092290 + 930 WP_007871963.1 formate dehydrogenase accessory protein FdhE -
N1710_RS19195 (N1710_19195) 4092364..4092654 - 291 WP_007871962.1 NadS family protein Antitoxin
N1710_RS19200 (N1710_19200) 4092654..4092965 - 312 WP_054623952.1 hypothetical protein Toxin
N1710_RS19205 (N1710_19205) 4093140..4093964 - 825 WP_007899185.1 AraC family transcriptional regulator -
N1710_RS19210 (N1710_19210) 4094225..4095628 + 1404 WP_105568618.1 MFS transporter -
N1710_RS19215 (N1710_19215) 4095640..4097607 + 1968 WP_105568617.1 glycoside hydrolase family 127 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12155.11 Da        Isoelectric Point: 9.7588

>T257178 WP_054623952.1 NZ_CP104108:c4092965-4092654 [Cronobacter sakazakii]
MLFIETEIFTRAVTALLSDDDYQRLQWFLALRPDYGDVIPDTGGLRKVRWLSGGRGKRGGVRIIYFYRPVDDEIRLLLIY
RKGIKDDLSPHEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10659.23 Da        Isoelectric Point: 10.7279

>AT257178 WP_007871962.1 NZ_CP104108:c4092654-4092364 [Cronobacter sakazakii]
MDKALFEQLTESLRQMNDISEGRREPSRVFVIDALKIKAIREASGLSQTKFASLISVSVDTLRNWEQGRRSPTGPARALL
RAIANDPQHVLSALAL

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A855WMY7

Antitoxin

Source ID Structure

References