Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1414838..1415485 Replicon chromosome
Accession NZ_CP104108
Organism Cronobacter sakazakii strain USDA-ARS-USMARC-54664

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N1710_RS06630 Protein ID WP_105546258.1
Coordinates 1414838..1415185 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V5TYW5
Locus tag N1710_RS06635 Protein ID WP_007776551.1
Coordinates 1415186..1415485 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1710_RS06605 (N1710_06605) 1410109..1411119 + 1011 WP_004387466.1 galactose/methyl galactoside ABC transporter permease MglC -
N1710_RS06610 (N1710_06610) 1411640..1412353 - 714 WP_004387784.1 outer membrane permeability protein SanA -
N1710_RS06615 (N1710_06615) 1412478..1413362 - 885 WP_105546257.1 cytidine deaminase -
N1710_RS06620 (N1710_06620) 1413492..1414187 - 696 WP_007869369.1 CidB/LrgB family autolysis modulator -
N1710_RS06625 (N1710_06625) 1414184..1414585 - 402 WP_097641629.1 CidA/LrgA family protein -
N1710_RS06630 (N1710_06630) 1414838..1415185 + 348 WP_105546258.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1710_RS06635 (N1710_06635) 1415186..1415485 + 300 WP_007776551.1 XRE family transcriptional regulator Antitoxin
N1710_RS06640 (N1710_06640) 1415558..1416490 + 933 WP_012124281.1 tRNA dihydrouridine(16) synthase DusC -
N1710_RS06645 (N1710_06645) 1416493..1417416 - 924 WP_104671343.1 LysR family transcriptional regulator -
N1710_RS06650 (N1710_06650) 1417489..1418448 + 960 WP_105546259.1 MBL fold metallo-hydrolase -
N1710_RS06655 (N1710_06655) 1418485..1418568 - 84 WP_000691708.1 small membrane protein YohP -
N1710_RS06660 (N1710_06660) 1418741..1419514 + 774 WP_105546260.1 SDR family oxidoreductase -
N1710_RS06665 (N1710_06665) 1419511..1420077 - 567 WP_105546261.1 DedA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-83)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13471.79 Da        Isoelectric Point: 10.3525

>T257171 WP_105546258.1 NZ_CP104108:1414838-1415185 [Cronobacter sakazakii]
MWTIYLTHEFECWLARQPQPLQEDVLAALGLLKIKGPHLGRPYADTLKGSRHTGMKALRVQHAVRPIRAFYAFDPHRYAI
VLCAAQKKGDEKRFYRVMLRVADKLFSHYLNHREV

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11035.67 Da        Isoelectric Point: 5.1667

>AT257171 WP_007776551.1 NZ_CP104108:1415186-1415485 [Cronobacter sakazakii]
MKTFDEVLAAQTPEARARIEEKTAQLLLETHLYALREALSVSQTEMARQMGIAQPSVAAIEQRGNEMKISTLKRYVEALG
GTVRLDVELPDGQRFGFTL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9UA72

References