257106

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4194294..4194896 Replicon chromosome
Accession NZ_CP104049
Organism Salmonella enterica subsp. enterica serovar Kentucky strain Sal-FJ2064

Toxin (Protein)


Gene name higB Uniprot ID A0A603E470
Locus tag NXZ70_RS20525 Protein ID WP_023138876.1
Coordinates 4194294..4194605 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag NXZ70_RS20530 Protein ID WP_000362052.1
Coordinates 4194606..4194896 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NXZ70_RS20490 (4189407) 4189407..4190006 + 600 WP_000965695.1 glucose-1-phosphatase -
NXZ70_RS20495 (4190000) 4190000..4190872 + 873 WP_000921423.1 virulence factor BrkB family protein -
NXZ70_RS20500 (4190869) 4190869..4191306 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
NXZ70_RS20505 (4191351) 4191351..4192292 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
NXZ70_RS20510 (4192307) 4192307..4192753 - 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin -
NXZ70_RS20515 (4192750) 4192750..4193061 - 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin -
NXZ70_RS20520 (4193147) 4193147..4194076 - 930 WP_001127698.1 alpha/beta hydrolase -
NXZ70_RS20525 (4194294) 4194294..4194605 + 312 WP_023138876.1 hypothetical protein Toxin
NXZ70_RS20530 (4194606) 4194606..4194896 + 291 WP_000362052.1 DNA-binding transcriptional regulator Antitoxin
NXZ70_RS20535 (4194943) 4194943..4195872 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
NXZ70_RS20540 (4195869) 4195869..4196504 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
NXZ70_RS20545 (4196501) 4196501..4197403 - 903 WP_000331361.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(37-74)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12356.30 Da        Isoelectric Point: 9.4460

>T257106 WP_023138876.1 NZ_CP104049:4194294-4194605 [Salmonella enterica subsp. enterica serovar Kentucky]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGSRGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10970.65 Da        Isoelectric Point: 11.0303

>AT257106 WP_000362052.1 NZ_CP104049:4194606-4194896 [Salmonella enterica subsp. enterica serovar Kentucky]
MDKVLFERLTQSMSQMNEIIEGTRKPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A603E470

Antitoxin

Source ID Structure

References