257018

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2458500..2459017 Replicon chromosome
Accession NZ_CP104020
Organism Staphylococcus aureus strain 0831

Toxin (Protein)


Gene name yoeB Uniprot ID T1YC79
Locus tag N0J69_RS12185 Protein ID WP_000113262.1
Coordinates 2458751..2459017 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A5A8VWS3
Locus tag N0J69_RS12180 Protein ID WP_000584502.1
Coordinates 2458500..2458751 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0J69_RS12150 (2454201) 2454201..2454920 + 720 WP_000479576.1 amino acid ABC transporter permease -
N0J69_RS12155 (2454917) 2454917..2455648 + 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
N0J69_RS12160 (2455745) 2455745..2456995 - 1251 WP_001012222.1 FemA/FemB family glycyltransferase FmhA -
N0J69_RS12165 (2457250) 2457250..2457609 + 360 WP_000819847.1 DUF4467 domain-containing protein -
N0J69_RS12170 (2457628) 2457628..2458227 + 600 WP_000162813.1 DsbA family protein -
N0J69_RS12175 (2458234) 2458234..2458335 + 102 WP_001791744.1 hypothetical protein -
N0J69_RS12180 (2458500) 2458500..2458751 + 252 WP_000584502.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N0J69_RS12185 (2458751) 2458751..2459017 + 267 WP_000113262.1 Txe/YoeB family addiction module toxin Toxin
N0J69_RS12190 (2459052) 2459052..2459123 + 72 Protein_2369 hypothetical protein -
N0J69_RS12195 (2459312) 2459312..2460862 + 1551 WP_000727762.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
N0J69_RS12200 (2461048) 2461048..2461515 + 468 WP_000153344.1 SRPBCC domain-containing protein -
N0J69_RS12205 (2461599) 2461599..2461781 + 183 WP_000230294.1 hypothetical protein -
N0J69_RS12210 (2461998) 2461998..2462822 + 825 WP_000572040.1 formate/nitrite transporter family protein -
N0J69_RS12215 (2463055) 2463055..2463591 + 537 WP_000169317.1 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.95 Da        Isoelectric Point: 9.9143

>T257018 WP_000113262.1 NZ_CP104020:2458751-2459017 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRNGALEGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9417.65 Da        Isoelectric Point: 4.4702

>AT257018 WP_000584502.1 NZ_CP104020:2458500-2458751 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSVMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6L8G
PDB 6L8F
PDB 7CUA
PDB 6L8E

Antitoxin

Source ID Structure
AlphaFold DB A0A5A8VWS3

References