257016

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2401645..2402168 Replicon chromosome
Accession NZ_CP104020
Organism Staphylococcus aureus strain 0831

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag N0J69_RS11910 Protein ID WP_000074048.1
Coordinates 2401902..2402168 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag N0J69_RS11905 Protein ID WP_000587616.1
Coordinates 2401645..2401902 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0J69_RS11885 (2396725) 2396725..2397918 + 1194 WP_000675401.1 MFS transporter -
N0J69_RS11890 (2398142) 2398142..2398891 - 750 WP_000072444.1 CPBP family lipoprotein N-acylation protein LnsB -
N0J69_RS11895 (2399086) 2399086..2400663 + 1578 WP_000143503.1 FMN-binding glutamate synthase family protein -
N0J69_RS11900 (2400831) 2400831..2401286 - 456 WP_000732082.1 DUF1307 domain-containing protein -
N0J69_RS11905 (2401645) 2401645..2401902 + 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
N0J69_RS11910 (2401902) 2401902..2402168 + 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
N0J69_RS11915 (2402523) 2402523..2403599 + 1077 WP_260050233.1 M42 family metallopeptidase -
N0J69_RS11920 (2403847) 2403847..2404509 + 663 WP_000923520.1 ATP-binding cassette domain-containing protein -
N0J69_RS11925 (2404502) 2404502..2405278 + 777 WP_000072147.1 iron export ABC transporter permease subunit FetB -
N0J69_RS11930 (2405674) 2405674..2406861 + 1188 WP_000026194.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T257016 WP_000074048.1 NZ_CP104020:2401902-2402168 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT257016 WP_000587616.1 NZ_CP104020:2401645-2401902 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References