257010

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-SprF1/-
Location 18831..19169 Replicon chromosome
Accession NZ_CP104020
Organism Staphylococcus aureus strain 0831

Toxin (Protein)


Gene name txpA Uniprot ID Q2FWU9
Locus tag N0J69_RS00105 Protein ID WP_011447039.1
Coordinates 18831..19007 (+) Length 59 a.a.

Antitoxin (RNA)


Gene name SprF1
Locus tag -
Coordinates 18995..19169 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0J69_RS00085 14066..17851 + 3786 WP_000582165.1 phage tail spike protein -
N0J69_RS00090 17841..17993 + 153 WP_001153681.1 hypothetical protein -
N0J69_RS00095 18040..18327 + 288 WP_001040261.1 hypothetical protein -
N0J69_RS00100 18385..18681 + 297 WP_000539688.1 DUF2951 domain-containing protein -
N0J69_RS00105 18831..19007 + 177 WP_011447039.1 type I toxin-antitoxin system toxin PepG1 Toxin
- 18995..19169 - 175 - - Antitoxin
N0J69_RS00115 19219..19473 + 255 WP_000611512.1 phage holin -
N0J69_RS00120 19485..20240 + 756 WP_000861038.1 CHAP domain-containing protein -
N0J69_RS00125 20431..20922 + 492 WP_000919350.1 staphylokinase -
N0J69_RS00130 21572..21907 + 336 Protein_25 SH3 domain-containing protein -
N0J69_RS00135 22002..22451 - 450 WP_000727649.1 chemotaxis-inhibiting protein CHIPS -
N0J69_RS00140 23136..23486 + 351 WP_000702263.1 complement inhibitor SCIN-A -
N0J69_RS00145 23539..23799 - 261 WP_001791826.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sak / chp / scn 1..23486 23485


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(30-58)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6849.45 Da        Isoelectric Point: 10.6777

>T257010 WP_011447039.1 NZ_CP104020:18831-19007 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Download         Length: 177 bp

Antitoxin


Download         Length: 175 bp

>AT257010 NZ_CP104020:c19169-18995 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7NS1

Antitoxin

Download structure file

References