Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4706210..4706812 Replicon chromosome
Accession NZ_CP104014
Organism Enterobacter sp. CP102

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N1249_RS22230 Protein ID WP_259833481.1
Coordinates 4706501..4706812 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N1249_RS22225 Protein ID WP_259833479.1
Coordinates 4706210..4706500 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N1249_RS22210 (N1249_22210) 4703708..4704610 + 903 WP_014072386.1 formate dehydrogenase subunit beta -
N1249_RS22215 (N1249_22215) 4704607..4705242 + 636 WP_008501832.1 formate dehydrogenase cytochrome b556 subunit -
N1249_RS22220 (N1249_22220) 4705239..4706168 + 930 WP_014072388.1 formate dehydrogenase accessory protein FdhE -
N1249_RS22225 (N1249_22225) 4706210..4706500 - 291 WP_259833479.1 NadS family protein Antitoxin
N1249_RS22230 (N1249_22230) 4706501..4706812 - 312 WP_259833481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N1249_RS22235 (N1249_22235) 4707042..4707959 + 918 WP_259833483.1 alpha/beta hydrolase -
N1249_RS22240 (N1249_22240) 4707976..4708917 - 942 WP_259833486.1 fatty acid biosynthesis protein FabY -
N1249_RS22245 (N1249_22245) 4708962..4709399 - 438 WP_014072393.1 D-aminoacyl-tRNA deacylase -
N1249_RS22250 (N1249_22250) 4709396..4710277 - 882 WP_259833488.1 virulence factor BrkB family protein -
N1249_RS22255 (N1249_22255) 4710271..4710870 - 600 WP_014072395.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12173.29 Da        Isoelectric Point: 9.9665

>T257009 WP_259833481.1 NZ_CP104014:c4706812-4706501 [Enterobacter sp. CP102]
MLFIETEIFTEDVKLLLDDDEYRKLQVFLAMQPDYGDLIQNTGGLRKIRWLAGGKGKRGGVRVIYFHRTREFEIRLLLIY
RKGIKDDLSATEKAVLKKIIERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10744.25 Da        Isoelectric Point: 10.7342

>AT257009 WP_259833479.1 NZ_CP104014:c4706500-4706210 [Enterobacter sp. CP102]
MDKALFERLTQSMAQMNEIAEGRRDPSRTFQIDAMKIKEIRQASGLSQSKFANLISVSVDTLRNWEQGRRSPTGPAQALL
RAIANDPQHVIPALSH

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References